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  • Preeclampsia Registry

Your participation in action

How does DNA relate to the physical symptoms of preeclampsia?



Dr. Sandra Founds from the University of Pittsburgh School of Nursing completed a pilot study to look at a set of genes (genotypes) in DNA and how they relate to the physical symptoms of preeclampsia.  Because of your contributions, the Registry was able to provide Dr. Founds with the necessary information.

The study aimed to identify women's symptoms of preeclampsia, such as swelling or headaches, and explore these symptoms with genes that may be linked to preeclampsia (also called "candidate genes").  Over 100 Registry participants with completed enrollment surveys and DNA samples were included in this study.  8 single nucleotide polymorphisms (SNPs), often called "snips", were evaluated in 4 preeclampsia candidate genes.  SNPs are genetic differences that can act as biological markers for scientists to learn more about certain conditions.  Of the 17 symptoms that were studies, 6 were associated with 4 SNPs, and 7 symptoms were affected in 8 genotypes.

This research learned that certain preeclampsia symptoms can be linked with certain genes, and that it would be reasonable for scientists to consider symptoms in future genetic research of preeclampsia.  Future studies to validate these findings could lead to a better understanding of the characteristics of preeclampsia in an effort to better predict, prevent, and provide early precision care to mothers and their babies.

Your help with this study adds another piece to the preeclampsia puzzle, thank you.